In the title compound, {[NiCl2(C19H17N5O2)2]·4C3H7NO}n, the NiII atom is located on an inversion centre and is in a six‐coordinated octahedral geometry, formed by four pyridine N atoms from four N2,N6‐bis[(pyridin‐3‐yl)methyl]pyridine‐2,6‐dicarboxamide (BPDA) ligands occupying the equatorial plane and two chloride anions at the axial sites. The bidentate bridging BPDA ligands link the NiII atoms into a two‐dimensional corrugated grid‐like flexible layer with a (4,4)‐connected topology, which consists of left‐ and right‐handed helical chains sharing the common NiII atoms. Investigation of the thermal stability shows that the network is stable up to 573 K.