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Left Panel: Lung tissue from a mouse 28 days post‐treatment with bleomycin. The tissue section, which was stained with Gomori's Trichrome stain shows increased collagen (blue) in the lung parenchyma. Right Panel: In situ binding assay showing the binding of rhCXCL8 to alveolar macrophages, alveolar septa, and the cell surface of airway epithelial cells. In this confocal image, rhCXCL8 is stained red,...
The extracellular domain of several membrane‐anchored proteins is released from the cell surface as soluble proteins through a regulated proteolytic mechanism called ectodomain shedding. Cells use ectodomain shedding to actively regulate the expression and function of surface molecules, and modulate a wide variety of cellular and physiological processes. Ectodomain shedding rapidly converts membrane‐associated...
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