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Primary central nervous system‐diffuse large B‐cell lymphoma (PCNS‐DLBCL) is a rare, extranodal malignant lymphoma carrying poor prognosis. The prognostic impact of tumor microenvironment (TME) composition and the PD‐1/PD‐L1 immune checkpoint pathway are still undetermined in PCNS‐DLBCL. We aimed to quantify the tumor‐infiltrating lymphocytes (TILs), tumor‐associated macrophages (TAMs), and PD‐L1...
Biofilm infections involving orthopedic implants are a global problem. They contribute to severe complications and mortality, as well as increased use of antibiotic treatments and development of antibiotic‐resistant microorganisms. More than 1 million hip and knee arthroplasties are performed each year in the United States. These hard‐to‐treat infections lead to patient distress, increased morbidity,...
The aim was to determine the accuracy of anterior nasal swab in rapid antigen (Ag) tests in a low SARS‐CoV‐2 prevalence and massive screened community. Individuals, aged 18 years or older, who self‐booked an appointment for real‐time reverse transcriptase‐polymerase chain reaction (RT‐PCR) test in March 2021 at a public test center in Copenhagen, Denmark were included. An oropharyngeal swab was collected...
In the milieu of coronavirus disease 2019 (COVID‐19), there are increasing reports of paediatric hyperinflammatory conditions (PHICs), including multisystem inflammatory syndrome in children (MIS‐C), paediatric multisystem inflammatory syndrome temporally associated with SARS‐CoV‐2 (PIMS‐TS) and Kawasaki disease (KD). Few analyses of PHIC prevalence in paediatric and adolescent hospitalized COVID‐19...
Antibiotic prophylaxis is a key element in prevention of surgical site infections. For the majority of orthopedic procedures, antibiotic administration follows fixed dosing regimens irrespective of weight. However, this may result in insufficient antibiotic target tissue concentrations and higher risk of surgical site infections in obese individuals. The aim of this study was to investigate the effect...
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