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Aim: Skeletal muscle interleukin‐6 (IL‐6) expression is induced by continuous contraction, overload‐induced hypertrophy and during muscle regeneration. The loss of IL‐6 can alter skeletal muscle’s growth and extracellular matrix remodelling response to overload‐induced hypertrophy. Insulin‐like growth factor‐1 (IGF‐1) gene expression and related signalling through Akt/mTOR is a critical regulator...
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