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BackgroundEpidemiological studies related poor maternal nutrition and subsequent growth retardation in the progeny to the development of diabetes later in life. Low‐protein diet during gestation altered the beta‐cell development of the rat progeny by decreasing beta‐cell proliferation and increasing their sensitivity to nitric oxide and cytokines in the foetus. This disturbed maternal environment...
It is becoming increasingly recognized that early‐life nutritional, metabolic and environmental factors can have a long‐term impact on the early onset of obesity, type 2 diabetes and cardiovascular diseases. Numerous experimental and epidemiological observations support the concept that an individual's response to their adult lifestyle and nutritional environment depends not only on their genetic...
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