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The modulation of nucleic acids by small molecules is an essential process across the kingdoms of life. Targeting nucleic acids with small molecules represents a significant challenge at the forefront of chemical biology. Nucleic acid junctions are ubiquitous structural motifs in nature and in designed materials. Herein, we describe a new class of structure‐specific nucleic acid junction stabilizers...
Rational entworfene Binder für Nucleinsäurekreuzungen mit einem Triptycengerüst stabilisieren DNA‐ und RNA‐Drei‐Wege‐Kreuzungen (3WJs) signifikant. In der Zuschrift auf S. 13966 ff. berichten D. M. Chenoweth und S. A. Barros, dass das Gerüst eine neue Architektur für die Entwicklung von Kreuzungsbindern mit verbesserten Erkennungseigenschaften bietet. Erste Zytotoxizitätsdaten bei zwei menschlichen...
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