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Kohlenwasserstoff‐Klammern als Proteinseitenkettenmimetika können die Konformation und/oder die Affinität für ein Zielprotein beeinflussen. In ihrer Zuschrift auf S. 4324 ff. diskutieren T. W. Moore et al. die strukturellen Folgen des Austauschs von Leucin und Isoleucin durch γ‐Methyl‐substituierte “heftklammerartige” Aminosäuren. Kristallstrukturen und Molekulardynamiksimulationen geben Einblick...
“Stapled” peptides are typically designed to replace two non‐interacting residues with a constraining, olefinic staple. To mimic interacting leucine and isoleucine residues, we have created new amino acids that incorporate a methyl group in the γ‐position of the stapling amino acid S5. We have incorporated them into a sequence derived from steroid receptor coactivator 2, which interacts with estrogen...
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