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Background
Testicular magnetic resonance imaging parameters, including apparent diffusion coefficient, fractional anisotropy, magnetization transfer ratio, and normalized metabolite concentrations represent useful noninvasive fingerprints of nonobstructive azoospermia. Nonobstructive azoospermia etiology might correlate with the spermatogenesis status.
Objectives
To assess the possible association...
Background
Quarterly intramuscular injections with long‐acting testosterone undecanoate (TU) provide stable serum testosterone concentrations over time and are therefore preferred by many testosterone‐deficient patients. However, the use of long‐acting TU in elderly patients is limited due to lack of safety and feasibility studies.
Objective
To investigate long‐acting TU pharmacokinetics and assess...
Background
Premature ejaculation (PE) is a highly prevalent male sexual dysfunction. Its current definition, together with the most used diagnostic tools, does not include nonvaginal sexual intercourse such as anal sex, self‐masturbation and/or partnered‐masturbation, and other forms of sexual stimulation. However, diagnostic psychometry currently available is exclusively evaluating PE in the vaginal...
Background
Spermatogenesis arrest and spermatogenic cell apoptosis occur in the testes of heat‐stressed mice. Although heat stress‐induced spermatogenic cell apoptosis is due to the decreased expression of cold‐inducible RNA‐binding protein (CIRBP), it remains unclear whether spermatogenesis arrest is also affected by CIRBP. Additionally, the specific mechanism by which CIRBP regulates spermatogenic...
Background
Autologous hematopoietic stem cell transplantation (AHSCT) is associated with sexual dysfunction and hypogonadism. Androgens are associated with sexual function in healthy men, but the role of estrogens is less well‐known, and the association of these sex steroids with sexual function during AHSCT has not been characterized.
Objectives
The purpose of this study was to determine the predictive...
Background
Genital‐based gender affirmation surgery is a physically demanding procedure requiring extensive postoperative pain management. However, perioperative opioid use for these procedures is relatively understudied.
Objectives
This study analyzes whether intravenous patient‐controlled analgesia (PCA) enhances pain control after penile inversion vaginoplasty (PIV) in the setting of enhanced...
Background
Congenital unilateral absence of vas deferens has been diagnosed in fertile and normozoospermic males and is associated with the risk of unilateral renal absence or cystic fibrosis transmembrane conductance regulator mutations; but no prediction model currently exists to diagnose this condition.
Objectives
The study aims to identify clinical and biological variables that may have a predictive...
Background
Cryptorchidism is one of the most common urogenital malformations. Cryptorchidism prevalence varies greatly in different countries and populations. The aim of the current study was to determine and analyse cryptorchidism prevalence in Estonia.
Materials and methods
During 2012–2015, all consecutively born 5014 boys at Tartu University Hospital were examined for cryptorchidism. All the...
Background
The population with diabetes mellitus‐induced erectile dysfunction is increasing rapidly, but current drugs are not effective in treating erectile dysfunction. Studies of the traditional Chinese medicine extract berberine on diabetes and its complications provide us with new ideas.
Objectives
To evaluate the therapeutic effect and potential mechanism of berberine on the erectile function...
Backgrounds
Sterility induced by anti‐cancer treatments has caused significant concern, yet the mechanism and treatment exploration are little for male infertility after cancer therapy. Busulfan, the antineoplastic that was widely applied before bone marrow transplantation, was known to induce male reproductive disorder.
Objectives
To investigate the effect of busulfan on blood–testis barrier function...
Background
Polyphenylene carboxymethylene (PPCM) sodium salt is a promising multipurpose technology for prevention of both sexually transmitted infections (STIs) and pregnancy. In preclinical studies, PPCM has demonstrated significant (1) antimicrobial activity against several important viral and bacterial pathogens and (2) contraceptive activity associated with premature acrosome loss.
Objective...
Background
An explosive increase in couples attending assisted reproductive technology has been recently observed, despite an overall success rate of about 20%–30%. Considering the assisted reproductive technology‐related economic and psycho‐social costs, the improvement of these percentages is extremely relevant. However, in the identification of predictive markers of assisted reproductive technology...
Background
Currently, there is no consensus on the effect of obstructive sleep apnea on male serum testosterone levels. This systematic review and meta‐analysis aimed to determine the association between obstructive sleep apnea and male serum testosterone level.
Methods
The literature related to obstructive sleep apnea and male serum testosterone in the PubMed, Embase, and Cochrane Library databases...
Background
Testicular tissue freezing is proposed for fertility preservation to (pre)pubertal boys with cancer before highly gonadotoxic treatment. Studies accurately comparing human (pre)pubertal testicular tissue quality before freezing and after thawing are exceptional. No study has reported this approach in a systematic manner and routine care.
Objectives
To assess the impact of a control slow...
Background
To improve symptoms associated with testosterone deficiency, many testosterone therapies are available that aim to restore serum testosterone (T) levels to the normal physiologic range. The magnitude, frequency, and duration between peak and trough T concentrations vary with route of administration, and none reflect normal endogenous daily diurnal T variations.
Objective
To compare pharmacokinetic...
Background
There has been recent interest in the use of botulinum neurotoxin (BoNT) in the field of Andrology, whereby it has been investigated in the treatment of penile retraction and premature ejaculation.
Objectives
To evaluate the safety and efficacy of intracavernosal BoNT‐A injection in the treatment of patients with erectile dysfunction (ED) refractory to oral phosphodiesterase inhibitors...
Background
Cryopreservation can expand the usefulness of spermatogonial stem cells (SSCs) in various fields. However, previous investigations that have attempted to modulate cryoinjury‐induced mechanisms to increase cryoprotective efficiency have mainly focused on apoptosis and necrosis.
Objectives
This study aimed to establish an effective molecular‐based cryoprotectant for SSC cryopreservation...
Background
: Oncostatin M (OSM) is a member of the interleukin‐6 group of cytokines, which can regulate cell proliferation, growth, and function. Immature Leydig cells have the ability to proliferate and differentiate, and adult Leydig cells have the function of testosterone synthesis. However, the role and underlying mechanisms of OSM on the proliferation and function of Leydig cells remain unclear...
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