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Spermatozoa produce increasing levels of reactive oxygen species (ROS) during development. We examined the functional organisation of NOX‐2 subunits in developing spermatozoa and its involvement in ROS generation. We found NOX‐2 components associated predominantly with caveolin‐rich microdomains of sperm head and mid piece membranes. Capacitation in vitro enriched NOX‐2 components within the caveolin‐positive...
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