The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
BackgroundEosinophilic esophagitis (EoE) is a chronic, Th2‐type inflammatory disease. Chemoattractant receptor‐homologous molecule on Th2 cells (CRTH2) is a prostaglandin D2 (PGD2) receptor, expressed by Th2 cells and other inflammatory cells, including eosinophils and basophils, that mediates chemotaxis and activation. OC000459 is a selective CRTH2 antagonist and would be expected to suppress eosinophilic...
BackgroundFarm‐derived dust samples have been screened for bacteria with potential allergo‐protective properties. Among those was Staphylococcus sciuri W620 (S. sciuri W620), which we tested with regard to its protective capacities in murine models of allergic airway inflammation.
MethodsWe employed two protocols of acute airway inflammation in mice administering either ovalbumin (OVA) or house dust...
BackgroundThe importance of serum basal tryptase (sBT) levels on patients with venom allergy is highlighted in recent adulthood studies. The aim of this study was to evaluate the sBT levels of venom‐allergic children with varying severity of clinical reactions. We also aimed to document the association between sBT levels and severe systemic reactions (SR).
MethodsSerum basal tryptase levels were...
BackgroundThe harmful effects of tobacco smoke on human health, including respiratory health, are extensive and well documented. Previous data on the effect of smoking on rhinitis and allergic sensitization are inconsistent. We sought to investigate how smoking correlates with prevalence of allergic and chronic rhinitis among adults in Sweden.
MethodsThe study population comprised 27 879 subjects...
BackgroundEosinophils and their products, including leukotrienes and eosinophil cationic protein (ECP), are well‐known mediators of inflammation and tissue damage in asthma. The antimicrobial peptide LL‐37 exhibits a variety of immunomodulatory activities. However, the role of LL‐37 in asthma has not been fully addressed. Here, we aim to investigate the effect of LL‐37 on inducing inflammatory mediators...
BackgroundThe major allergens in Parietaria pollen, Par j 1 and Par j 2, have been identified as lipid transfer proteins. The family of the Par j 1 allergens is composed of two isoforms, which differ by the presence of a 37 amino acid peptide (Par37) exclusive to the Par j 1.0101 isoform. The goal of this study was to elucidate the biological properties of the Par37 peptide.
MethodsIn silico analysis,...
BackgroundThe aim of this study was to evaluate the efficacy and safety of acupuncture in the treatment for allergic rhinitis.
MethodsThis study was a multicenter, randomized, parallel‐controlled study. Participants were randomized to either the active acupuncture, sham acupuncture, or waitlist groups. The active and sham acupuncture groups received acupuncture treatment three times per week for...
BackgroundNeonatal Bacillus Calmette–Guérin (BCG) vaccination induces vigorous T‐helper type 1 (Th1) responses and inhibits allergy‐related airway dysfunction, but the exact mechanisms remain unclear. The objective of this study was to address where the Th1 cells induced by neonatal BCG vaccination are generated and stored, and how they are recruited into the inflamed airway for the prevention of...
BackgroundGenetic susceptibility and environmental influences are important contributors to the development of asthma and atopic diseases. Epigenetic mechanisms may facilitate gene by environment interactions in these diseases.
MethodsWe studied the rural birth cohort PASTURE (Protection against allergy: study in rural environments) to investigate (a) whether epigenetic patterns in asthma candidate...
BackgroundEosinophils are involved in several inflammatory processes including allergic inflammation. It has been shown that eosinophil functions may be regulated by activating or inhibitory receptors. Hypoxia is a feature of inflamed tissues and has recently been shown to regulate eosinophil viability and pro‐angiogenic potential. In this study, the effect of hypoxia and GM‐CSF on the inhibitory...
Social determinants of asthma in adults and the very old have received little attention. Hence, it was aimed to examine social determinants of asthma in adults and the very old in a national population‐based setting. Data were analyzed in the UK Longitudinal Household Survey, 2009–2010. Information on demographics, living and work conditions, self‐reported ever asthma and age of onset was obtained...
Eosinophilic granulomatosis with polyangiitis (Churg–Strauss, EGPA) is a systemic small‐vessel vasculitis associated with asthma and eosinophilia. Histology of EGPA shows tissue eosinophilia, necrotizing vasculitis, and eosinophil‐rich granulomatous inflammation. EGPA commonly presents with upper airway tract and lung involvement, peripheral neuropathy, cardiac and skin lesions. Antineutrophil cytoplasmic...
Recurrent fever can be the sole or leading manifestation of a variety of diseases including malignancies, autoimmune diseases and infections. Because the differential diagnoses are manifold, no formal guidelines for the approach of patients with recurrent fever exists. The newly recognized group of autoinflammatory diseases are often accompanied by repetitive fever attacks. As these episodes are frequently...
BackgroundThere are conflicting study results regarding the association of exposure to visible mould and fungal components in house dust with respiratory and allergic diseases in children. It has been suggested that functional polymorphisms of the GSTP1 gene may influence the risk for allergic disorders through an impaired defence against oxidant injury.
MethodsWe examined in six birth cohorts of...
BackgroundMyeloid (m) and plasmacytoid (p) dendritic cells (DCs) regulate immune responses to allergens, whereas it remains unclear whether abnormal DC function characterizes patients with airway allergy and whether putative dysfunction exists only in target organs. To evaluate DC function from patients with allergic rhinitis (AR), we assessed nasal, cutaneous as well as blood DCs after in vivo and...
BackgroundMast cells (MC) are main effector cells of allergic and other inflammatory reactions; however, only a few anti‐MC agents are available for therapy. It has been reported that cinnamon extract (CE) attenuates allergic symptoms by affecting immune cells; however, its influence on MC was not studied so far. Here, we analyzed the effects of CE on human and rodent MC in vitro and in vivo.
MethodsExpression...
BackgroundAccording to current guidelines, skin testing for hymenoptera venom allergy should be performed in a stepwise manner, maintaining 15‐ to 20‐min intervals between the injections of venom. Given the long‐winded procedure of sequential skin testing, we retrospectively explored the safety of simultaneous intradermal testing.
MethodsFour hundred and seventy‐eight consecutive patients with a...
BackgroundA growing body of evidence has disclosed that allergic rhinitis (AR) is a systemic inflammatory disease. Inflammatory mediators and cells involved in AR have also been reported to be implicated in the process of atherosclerosis, which is relevant to the occurrence of erectile dysfunction (ED). Our objective was to explore the relationship between AR and future ED events.
MethodsFrom 1 January...
BackgroundAsthma and obesity are chronic multifactorial conditions that are associated with gene–environment interaction and immune function. Although the data are not fully consistent, it seems that obesity increases the risk of asthma and compromises asthma control.
ObjectiveTo investigate the impact that weight changes have on asthma.
MethodsWe carried out a systematic review of three large biomedical...
Patients with IgE antibodies against the carbohydrate epitope galactose‐α‐1,3‐galactose (α‐Gal) have reported severe allergic reactions after consumption of red meat. Investigations have revealed associations between IgE to α‐Gal and tick bites. We provide the first direct evidence that α‐Gal is present within ticks thus potentially explaining the relationship between tick exposure and sensitization...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.