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BackgroundThe Patient‐Oriented Eczema Measure (POEM) has been recommended as the core patient‐reported outcome measure for trials of eczema treatments. Using data from the Choice of Moisturiser for Eczema Treatment randomized feasibility study, we assess the responsiveness to change and determine the minimal clinically important difference (MCID) of the POEM in young children with eczema.
MethodsResponsiveness...
BackgroundNonsteroidal anti‐inflammatory drugs (NSAIDs) are among the most prevalent drugs inducing hypersensitivity reactions. The aim of this analysis was to estimate the prevalence of NSAID‐induced respiratory symptoms in population across Europe and to assess its association with upper and lower respiratory tract disorders.
MethodsThe GA2LEN survey was conducted in 22 centers in 15 European countries...
Aspergillus fumigatus is the causative agent of allergic broncho‐pulmonary aspergillosis. Prompt and accurate diagnosis may be difficult to achieve with current clinical and laboratory scores, which do not include immune responses to recombinant A. fumigatus allergens. We measured specific immunoglobulin E and G4 directed to recombinant A. fumigatus allergens in 55 cystic fibrosis patients without...
IgE sensitization tests, such as skin prick testing and serum‐specific IgE, have been used to diagnose IgE‐mediated clinical allergy for many years. Their prime drawback is that they detect sensitization which is only loosely related to clinical allergy. Many patients therefore require provocation tests to make a definitive diagnosis; these are often expensive and potentially associated with severe...
BackgroundAn individual's birth month has been associated with allergic diseases, but little is known about the association between birth month and atopic dermatitis (AD).
ObjectiveThe aim of this study was to investigate the risk of AD in children born in various months.
MethodsUsing Taiwan's National Health Insurance Research Database, we conducted a case–control study that included 31 237 AD...
BackgroundPresently, no validated data exist on symptom severity and disease‐specific quality‐of‐life (QoL) for patients with mastocytosis. Simultaneously, clinical trials and drug application processes increasingly mandate reporting patients’ perspectives on symptoms and QoL. We report on the development and validation of the mastocytosis quality‐of‐life questionnaire (MQLQ) and the mastocytosis...
BackgroundA major drawback of oral immunotherapy for food allergy is the possibility of severe side‐effects. We assessed both safety and efficacy of a low allergenic hydrolysed egg (HydE) preparation used in a double‐blind placebo‐controlled randomized study in egg allergic children.
MethodsIn a pilot multicentre study, 29 egg allergic patients (aged 1–5.5 years) were administered daily for 6 months...
BackgroundSignaling through histamine receptors on dendritic cells (DCs) may be involved in the effector phase of peanut‐induced intestinal anaphylaxis.
ObjectivesThe objective of this study was to determine the role of histamine H1 (H1R) and H4 receptors (H4R) in intestinal allergic responses in a model of peanut allergy.
MethodsBalb/c mice were sensitized and challenged with peanut. During the...
MeDALL (Mechanisms of the Development of ALLergy; EU FP7‐CP‐IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large‐scale and integrative approach: MeDALL data of precisely phenotyped children followed in...
Identification of allergen epitopes is a key component in proper understanding of the pathogenesis of type I allergies, for understanding cross‐reactivity and for the development of mimotope immunotherapeutics. Phage particles have garnered recognition in the field of molecular allergology due to their value not only in competitive immunoscreening of peptide libraries but also as immunogenic carriers...
While a number of allergens from house dust mites have been described, much remains to be discovered about allergens from storage mites. Here, next‐generation sequencing was combined with MS/MS shotgun proteomics to identify proteins, especially potential allergens from Tyrophagus putrescentiae, commonly found in stored food products, especially flour. cDNAs of suspected allergens were cloned and...
Stings in the head region are considered to be a risk factor for severe systemic reactions to hymenoptera stings. We supposed that stings in skin areas, which are well supplied with blood, lead to more severe reactions and tested our hypothesis in 847 patients with confirmed hymenoptera venom allergy. However, symptom severity was independent from sting site: only 16.3% of patients with severe reactions...
BackgroundThe UK's NHS intends to move from the current Read code system to the international, detailed Systematized Nomenclature of Medicine Clinical Terms (SNOMED‐CT) to facilitate more clinically appropriate coding of conditions and associated risk factors and outcomes. Given concerns about coding behaviour of general practitioners, we sought to study the current coding patterns in allergies and...
BackgroundAllergic Rhinitis Control Test (ARCT) has been validated for assessing allergic rhinitis (AR) control and identifying severe AR. The aim of the study was to assess the ARCT questionnaire as a tool for stepwise pharmacotherapy.
MethodsA standard pharmacotherapy regimen from Step 1 (oral second‐generation H1 antihistamine as needed) to Step 5 (oral corticosteroid) was carried out prospectively...
The strongest and best‐documented risk factor for drug hypersensitivity (DH) is the history of a previous reaction. Accidental exposures to drugs may lead to severe or even fatal reactions in sensitized patients. Preventable prescription errors are common. They are often due to inadequate medical history or poor risk assessment of recurrence of drug reaction. Proper documentation is essential information...
BackgroundIn a previously reported CoFAR study, 55 subjects with egg allergy underwent randomized, placebo‐controlled egg oral immunotherapy (eOIT). Active treatment induced desensitization in most and sustained unresponsiveness (SU) in a smaller subset. We hypothesized that component‐resolved analysis of IgE, IgG4, IgA, IgA1, and IgA2 may identify potential biomarkers of SU in OIT subjects.
MethodsLongitudinal...
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