Current literature relies almost exclusively on the power number to compare and characterize impellers. Industrial mixing requirements may rely on conditions far away from the impeller. A protocol is proposed to compare impellers designed for turbulent mixing on the basis of impeller hydrodynamic performance and mixing process objectives. A hydrofoil impeller (KPC), and a mixed‐flow impeller (45° down‐pumping PBT), each at two diameters, were used to test the protocol. Fourteen measures were considered. Five are recommended for full characterization: power number, momentum number, and peak rate of dissipation of turbulent kinetic energy to characterize conditions at the impeller; power at just‐suspended speed to compare the efficiency of solids suspension at the bottom of the tank; and point of air entrainment as a measure of turbulence penetration to the free surface. These five measures provide complete information about mixing performance and good differentiation between the impellers and geometries. © 2011 American Institute of Chemical Engineers AIChE J, 58: 2573–2588, 2012