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Nothofagin is a prominent bioactive ingredient of rooibos tea. We recently reported its synthesis through a glucosyltransferase cascade reaction involving 3′‐C‐β‐D‐glucosylation of the dihydrochalcone phloretin from uridine 5′‐diphosphate (UDP)‐glucose and in situ formation of UDP‐glucose from sucrose and catalytic amounts of UDP. Here we show that the limitation in process efficiency caused by the...
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