This review collects the very recent developments in enantioselective metal‐catalyzed domino reactions published since the beginning of 2016. It illustrates that many types of enantioselective metal‐catalyzed domino processes continue to be developed, allowing an easy one‐pot access to complex molecular architectures from simple starting materials while providing economic advantages, such as avoiding costly protecting groups and time‐consuming purification procedures after each step.
Abbreviations: acac: acetylacetonate; Ar: aryl; BINAP: 2,2′‐bis(diphenylphosphino)‐1,1′‐binaphthyl; BINOL: 1,1′‐bi‐2‐naphthol; Bn: benzyl; Boc: tert‐butoxycarbonyl; Box: bisoxazoline; BOXAX: 2,2′‐bis(oxazolyl)‐1,1′‐binaphthyl; Bz: benzoyl; cod: cyclooctadiene; Cy: cyclohexyl; DBDMH: 1,3‐dibromo‐5,5‐dimethylhydantoin; DBU: 1,8‐diazabicyclo[5.4.0]undec‐7‐ene; DCE: dichloroethane; de: diastereomeric excess; DIPEA: diisopropylethylamine; dr: diastereomeric ratio; ee: enantiomeric excess; Hex: hexyl; L: ligand; MTBE: methyl tert‐butyl ether; Naph: naphthyl; Ms: mesyl; M.S.: molecular sieves; NMP: N‐methyl‐2‐pyrrolidone; Ns: nosyl; PG: protecting group; Phos: phosphinyl; PHOX: phosphinooxazoline; Phth: phthaloyl; Pin: pinacolato; Piv: pivaloyl; Pybox: 2,6‐bis(2‐oxazolyl)pyridine; r.t.: room temperature; TBS: tert‐butyldimethylsilyl; Tf: trifluoromethanesulfonyl; TFA: trifluoroacetic acid; THF: tetrahydrofuran; TMS: trimethylsilyl; Tol: tolyl; Ts: 4‐toluenesulfonyl (tosyl).