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In article number 1807359, Hai‐Quan Mao, Jonathan P. Schneck, and co‐workers introduce an artificial T‐cell stimulating matrix (aTM), a biomimetic hydrogel‐based matrix that presents T‐cell stimulatory signals. The aTM with optimized stimulatory properties effectively potentiates T‐cell signaling, skews the phenotypes of both murine and human T cells, and ultimately generates anti‐tumor T cells that...
T cell therapies require the removal and culture of T cells ex vivo to expand several thousand‐fold. However, these cells often lose the phenotype and cytotoxic functionality for mediating effective therapeutic responses. The extracellular matrix (ECM) has been used to preserve and augment cell phenotype; however, it has not been applied to cellular immunotherapies. Here, a hyaluronic acid (HA)‐based...
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