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In article number 1808050, V. Prasad Shastri and co‐workers describe the formation of a new perfused blood vessel. The stabilization of this neovessel by a mechanically defined hydrogel microenvironment through the recruitment (extravasation) of mechanosensing CD11b+/piezo‐1+ cells by this microenvironment is depicted against the backdrop of a hematoxylin‐eosinstained image of a skeletal muscle.
Vascularization is a critical step in the restoration of cellular homeostasis. Several strategies including localized growth factor delivery, endothelial progenitor cells, genetically engineered cells, gene therapy, and prevascularized implants have been explored to promote revascularization. But, long‐term stabilization of newly induced vessels remains a challenge. It has been shown that fibroblasts...
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