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Cancer Therapy
In article number 2104037, Xiang Li, Zhen Gu, Xiujun Cai, and co‐workers report that the generated H2S and released zinc ions from ZnS@BSA nanoclusters promote accumulation of reactive oxygen species to activate cGAS/STING signals in tumor cells. ZnS@BSA nanoclusters are further demonstrated to facilitate antitumor immunotherapy by immune cell infiltration, showing potential for clinical...
Although immunotherapy such as immune checkpoint inhibitors has shown promising efficacy in cancer treatment, the responsiveness among patients is relatively limited. Activation of the cyclic guanosine monophosphate‐adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) signaling pathway to upregulate innate immunity has become an emerging strategy for enhancing tumor immunotherapy...
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