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The tumor microenvironment in the brain is complex, varying in space and time. On page 1567, B. A. Harley and co‐workers report the use of microfluidic forming tools to generate optically translucent hydrogels that contain overlapping gradients of cell, matrix, and bio‐molecular cues inspired by the tumor microenvironment. The inside back cover depicts the use of this platform to monitor the malignant...
There is an acute need for biomaterial tools that recreate the heterogeneous brain‐tumor microenvironment. A microfluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor‐inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the...
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