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Cancer Immunotherapy
In article number 2210986, Mingming Ding and co‐workers construct a photoallosteric polymersome (PAP) that undergoes a rapid conformational transition from β‐sheet to α‐helix upon exposure to near‐infrared light irradiation. Photoinduced allosteric behavior specifically enhances cell penetration and lysosome escape and reconstructs the vesicular membrane structure for on‐demand...
Allosteric transitions can modulate the self‐assembly and biological function of proteins. It remains, however, tremendously challenging to design synthetic allosteric polymeric assemblies with spatiotemporally switchable hierarchical structures and functionalities. Here, a photoallosteric polymersome is constructed that undergoes a rapid conformational transition from β‐sheet to α‐helix upon exposure...