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Pulsatile drug delivery systems have the potential to improve patient adherence and therapeutic efficacy by providing a sequence of doses in a single injection. Herein, a novel platform, termed Particles Uniformly Liquified and Sealed to Encapsulate Drugs (PULSED) is developed, which enables the high‐throughput fabrication of microparticles exhibiting pulsatile release. In PULSED, biodegradable polymeric...
Drug Delivery Systems
In article number 2300228, Tyler P. Graf, Kevin J. McHugh, and co‐workers describe the development of an injectable microparticle platform that enables delayed, pulsatile drug release after a material‐dependent delay. This high‐throughput fabrication method produces biodegradable particles that are capable of releasing protein in a bioactive state after a period of weeks, enabling...