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In article number 1807553, Hong Nam Kim, Elizabeth A. Lipke, Deok‐Ho Kim, and co‐workers describe recent advances in in vitro tumor models that can mimic the physical and biochemical features of the native tumor microenvironment. These microphysiological systems that reflect the physiology of the tumor microenvironment allow for the study of the mechanisms underlying tumor biology and the reliable...
Tumor cell heterogeneity with distinct phenotypes, genotypes, and epigenetic states as well as the complex tumor microenvironment is major challenges for cancer diagnosis and treatment. There have been substantial advances in our knowledge of tumor biology and in the capabilities of available biological analysis tools; however, the absence of physiologically relevant in vitro testing platforms limits...
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