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Background and Aims
Prescription opioid analgesics have contributed to the development of opioid use disorder (OUD) in many individuals. We aimed to characterize non‐cancer opioid prescribing for opioid‐naive individuals prior to OUD identification.
Design
Population‐based retrospective cohort study using six linked health administrative databases.
Setting
British Columbia (BC), Canada.
Participants...
Background and Aims
In a US randomized‐effectiveness trial comparing extended‐release naltrexone (XR‐NTX) with buprenorphine–naloxone (BUP‐NX) for the prevention of opioid relapse among participants recruited during inpatient detoxification (CTN‐0051), the requirement to complete opioid detoxification prior to initiating XR‐NTX resulted in lower rates of initiation of XR‐NTX (72% XR‐NTX versus 94%...
Aim
To test the effect of the duration of medication for opioid use disorder (MOUD) use during pregnancy on maternal, perinatal and neonatal outcomes.
Design
Retrospective cohort analysis of claims, encounter and pharmacy data.
Setting
Pennsylvania, USA.
Participants
We analyzed 13 320 pregnancies among 10 741 women with opioid use disorder aged 15–44 years enrolled in Pennsylvania Medicaid...
Background and aims
While long‐term medication‐assisted treatment (MAT) using methadone or buprenorphine is associated with significantly lower all‐cause mortality for individuals with opioid use disorder (OUD), periods of initiating or discontinuing treatment are associated with higher mortality risks relative to stable treatment. This study aimed to identify the OUD treatment durations necessary...
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