Alcoholism: Clinical and Experimental Research

Items from 1 to 14 out of 14 results

article

Profiling of extracellular vesicle‐bound miRNA to identify candidate biomarkers of chronic alcohol drinking in nonhuman primates

Sloan A. Lewis, Brianna Doratt, Suhas Sureshchandra, Tianyu Pan, more

Alcoholism: Clinical and Experimental Research > 46 > 2 > 221 - 231

Background Long‐term alcohol drinking is associated with numerous health complications including susceptibility to infection, cancer, and organ damage. However, due to the complex nature of human drinking behavior, it has been challenging to identify reliable biomarkers of alcohol drinking behavior prior to signs of overt organ damage. Recently, extracellular vesicle‐bound microRNAs (EV‐miRNAs) have...

article

Health‐related quality of life is dynamic in alcoholic hepatitis and responds to improvement in liver disease and reduced alcohol consumption

Abhishek Madathanapalli, Qing Tang, Craig Lammert, Niharika Samala, more

Alcoholism: Clinical and Experimental Research > 46 > 2 > 252 - 261

Background The impact of alcoholic hepatitis (AH) on health‐related quality of life (HRQOL) remains inadequately described. We aimed to characterize HRQOL in AH and heavy drinkers (HD), and its associations with clinical variables and outcomes. Methods This is a post hoc analysis of participants in the Translational Research and Evolving Alcoholic Hepatitis Treatment 001 study (NCT02172898). HRQOL...

article

Addressing methodological issues in a study of impulsivity and vulnerability for transition to alcohol use disorder

Antoinette Poulton, Oliver Eastwood, Loren Richard Bruns, Richard O. Sinnott, more

Alcoholism: Clinical and Experimental Research > 46 > 2 > 262 - 276

Background Heightened behavioral impulsivity has been advocated as a preexisting risk factor for the development of alcohol use disorder (AUD). Nonetheless, studies investigating impulsivity in adolescent/young adult at‐risk drinkers—who are at increased risk of developing AUD—report mixed findings. This may be due to methodological limitations related to definitions of at‐risk drinking, the retrospective...

article

Issue Information

Alcoholism: Clinical and Experimental Research > 46 > 2 > 189 - 192

article

Reciprocal associations between implicit attitudes and drinking in emerging adulthood

Katie J. Paige, Alexander Weigard, Craig R. Colder

Alcoholism: Clinical and Experimental Research > 46 > 2 > 277 - 288

Background Implicit alcohol attitudes are considered important in the etiology of drinking, and theory posits reciprocal associations between them. Research testing reciprocal associations between implicit attitudes (using the Implicit Association Task, IAT) and drinking is limited by a failure to consider multiple processes influencing performance on the IAT and to disaggregate within‐ and between‐person...

article

Astrogliosis and compensatory neurogenesis after the first ethanol binge drinking‐like exposure in the adolescent rat

Catherine Vilpoux, Gregory Fouquet, Chloe Deschamps, Elise Lefebvre, more

Alcoholism: Clinical and Experimental Research > 46 > 2 > 207 - 220

Background Multiple ethanol binge drinking‐like exposures during adolescence in the rat induce neuroinflammation, loss of neurogenesis, and cognitive deficits in adulthood. Interestingly, the first ethanol binge drinking‐like exposure during adolescence also induces short‐ term impairments in cognition and synaptic plasticity in the hippocampus though the cellular mechanisms of these effects are...

article

Articles of Public Interest

Alcoholism: Clinical and Experimental Research > 46 > 2 > 193 - 193

article

Dissociative symptomatology mediates the relation between posttraumatic stress disorder severity and alcohol‐related problems

Herry Patel, Charlene O’Connor, Krysta Andrews, Michael Amlung, more

Alcoholism: Clinical and Experimental Research > 46 > 2 > 289 - 299

Background Up to 50% of individuals with posttraumatic stress disorder (PTSD) endorse problematic alcohol use. Typically, these individuals present with more complex and often more severe PTSD symptoms than those who do not report problematic alcohol use. Emerging literature suggests that heightened symptoms of dissociation are likewise associated with greater PTSD symptom severity. Despite this...

article

Quantitation of phosphatidylethanols in dried blood spots to determine rates of prenatal alcohol exposure in Ontario

Alicia DiBattista, Svetlana Ogrel, Alex E. MacKenzie, Pranesh Chakraborty

Alcoholism: Clinical and Experimental Research > 46 > 2 > 243 - 251

Background Estimating rates of prenatal alcohol exposure (PAE) in a population is necessary to ensure that proper medical and social supports and interventions are in place. This study sought to estimate PAE in Ontario, Canada by quantifying phosphatidylethanol (PEth) homologues in over 2000 residual neonatal dried blood spots (DBS). Methods A random selection of 2011 residual DBS collected over...

article

Abstinence versus moderation recovery pathways following resolution of a substance use problem: Prevalence, predictors, and relationship to psychosocial well‐being in a U.S. national sample

David Eddie, Brandon G. Bergman, Lauren A. Hoffman, John F. Kelly

Alcoholism: Clinical and Experimental Research > 46 > 2 > 312 - 325

Background Many people who report resolving an alcohol or other drug (AOD) problem continue some level of substance use. Little information exists, however, regarding the prevalence of this resolution pathway, or how continued substance use after resolving an AOD problem, relative to abstinence, relates to functioning, quality of life, and happiness (i.e., well‐being). Greater knowledge of the prevalence...

article

Reduced calibration between subjective and objective measures of episodic future thinking in alcohol use disorder

Xavier Noël, Mélanie Saeremans, Charles Kornreich, Armand Chatard, more

Alcoholism: Clinical and Experimental Research > 46 > 2 > 300 - 311

Background A reduced capacity to mentally simulate future scenarios could be of clinical importance in alcohol use disorder (AUD). However, little is known about the mechanisms underlying episodic future thinking (EFT) impairment in AUD. Methods We tested patients with severe AUD using two measures of EFT: the individual's own subjective experience of their imaginings (phenomenology) and the objective...

article

Conditioned social preference and reward value of activating oxytocin‐receptor‐expressing ventral tegmental area neurons following repeated daily binge ethanol intake

Joanna Peris, Katye Totten, Darrice Montgomery, Hannah Lester, more

Alcoholism: Clinical and Experimental Research > 46 > 2 > 194 - 206

Background Individuals with alcohol use disorder (AUD) exhibit a disruption of social behavior and dysregulation of oxytocin signaling in the brain, possibly reflecting decreased activation of oxytocin receptors (OxTRs) in reward pathways in response to social stimuli. We hypothesize that daily binge ethanol intake causes a deficit in social reward and oxytocin signaling in the ventral tegmental...

article

Naltrexone moderates the association of alcohol use and affect among adolescent drinkers in daily life

Ryan W. Carpenter, Noah N. Emery, Samuel N. Meisel, Robert Miranda

Alcoholism: Clinical and Experimental Research > 46 > 2 > 326 - 337

Background Naltrexone is an efficacious medication for the treatment of alcohol use disorder in adults. As an opioid receptor antagonist, naltrexone blocks activation of the endogenous opioid system, which is involved in the affectively reinforcing properties of substance use. Few studies, however, have examined the moderating effect of naltrexone on the association between affect and alcohol use...

article

Prenatal alcohol exposure and mental health at midlife: A preliminary report on two longitudinal cohorts

Claire D. Coles, Therese M. Grant, Julie A. Kable, Susan A. Stoner, more

Alcoholism: Clinical and Experimental Research > 46 > 2 > 232 - 242

Background Although the effects of prenatal alcohol exposure (PAE) have been studied extensively, there is relatively little information available on adult mental health functioning among exposed individuals. The current study compares the self‐reported midlife mental health status of individuals who were prenatally exposed to alcohol and diagnosed in childhood with the effects of this exposure with...

Filter options

Number:
2
Volume:
46

Publication date

Last 3 years (14)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Keywords

ALCOHOL (3)
ALCOHOL USE DISORDER (3)
PRENATAL ALCOHOL EXPOSURE (2)
ABSTINENCE VERSUS CONTINUED SUBSTANCE USE (1)
ADOLESCENCE (1)
ADOLESCENTS (1)
ADVERSE CHILDHOOD EXPERIENCES (1)
ALCOHOL AND OTHER DRUG PROBLEM RESOLUTION (1)
ALCOHOLIC HEPATITIS (1)
ALCOHOLISM (1)
ALEXITHYMIA (1)
ASTROGLIOSIS (1)
BEHAVIORAL IMPULSIVITY (1)
BINGE DRINKING (1)
BINGE ETHANOL (1)
CANADIAN SAMPLE (1)
CHOICE IMPULSIVITY (1)
CHRONIC LIVER DISEASE (1)
DEPRESSION (1)
DISSOCIATION (1)
DRIED BLOOD SPOTS (1)
DUAL PROCESS THEORY (1)
ECOLOGICAL MOMENTARY ASSESSMENT (1)
EMERGING ADULTHOOD (1)
EPISODIC FUTURE THINKING (1)
EXTRACELLULAR VESICLES (1)
FETAL ALCOHOL SPECTRUM DISORDERS (1)
HEAVY DRINKING (1)
HIPPOCAMPUS (1)
IMPLICIT ATTITUDES (1)
MENTAL HEALTH (1)
METACOGNITION (1)
MIRNA (1)
NALTREXONE (1)
NEONATES (1)
NEUROINFLAMMATION (1)
NONHUMAN PRIMATES (1)
OXYTOCIN RECEPTOR (1)
PHOSPHATIDYLETHANOL (1)
POSTTRAUMATIC STRESS DISORDER (1)
PRIMARY AND SECONDARY SUBSTANCES (1)
QUALITY OF LIFE (1)
RECOVERY CAPITAL (1)
REINFORCEMENT (1)
RESPONSE INHIBITION (1)
RESPONSE TIME MEASURES (1)
SF‐36 (1)
SOCIAL REWARD (1)
TREATMENT‐SEEKING (1)
VENTRAL TEGMENTAL AREA (1)
WELL‐BEING (1)
more

INFONA - science communication portal

Alcoholism: Clinical and Experimental Research

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Reporting an error / abuse

Sending the report failed

Accessibility options