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Argonaute 2 (Ago2) has a leading function in miRNA‐induced RNA silencing, a conserved gene regulatory mechanism in cells and organisms. miRNAs are critical for stem cell self‐renewal, development, and other functions. Here, we report that nuclear Ago2, by binding to a specific region of functional genes, directly controls adipose tissue–derived stem cell (ATSC) survival in response to a critical dose...
Deletion of the p66Shc gene results in lean and healthy mice, retards aging, and protects from aging‐associated diseases, raising the question of why p66Shc has been selected, and what is its physiological role. We have investigated survival and reproduction of p66Shc−/− mice in a population living in a large outdoor enclosure for a year, subjected to food competition and exposed to winter temperatures...
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