For the last 20 years, pharmacological or mechanical reperfusion therapy, focused on restoration of patency of the infarct-related artery, has been the cornerstone of the initial treatment of acute myocardial infarction (AMI). A large number of clinical trials have shown that complete recanalization of the occluded epicardial coronary artery significantly improves short and long-term prognosis [1–3]. It has also been shown that in order to improve prognosis it is essential to minimize the time from onset of symptoms to recanalization of infarct-related artery [4].