As a result of some of the analogies between biology and transport, including the concepts of evolution and selection, we are wondering whether some ideas and methods used in biology may not be used to provide research avenues within the field of transportation. We are interested in the idea of complexity, which is common to the two scientific fields, but not treated in the same way by either of the two disciplines. By observing the way in which systemic biology has developed, from a largely “data-driven” approach to research guided by data, we are questioning whether such a direction would be possible in the field of transportation. This investigation also leads us to ask questions about “modules”, or the boundaries of the subsystems studied in the field of transportation, through the observation that molecular biology defines these boundaries in terms of the function of the subsystems. In conclusion, we are expressing the notion that these comparisons will lead to new research avenues in the field of transportation.