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Various antigen structures initiate the classical and the lectin pathways of complement activation. Multidomain modular proteases (C1r, C1s and MASPs) are involved in the initiation complexes of both pathways. Despite the identical domain organization of these serine proteases there are differences in their specificities and functions. A comparative analysis is given on the similarities and differences...
Clinical studies led to the discovery of complement deficient states several decades ago. With the advent of molecular biology the genetic basis of the deficient states has been revealed. In this chapter we review the current knowledge on the genetics of complement.
Complement receptors form a critical interface between extracellular complement activation and intracellular signaling. The proper cellular response to complement fragments depends on cell-specific expression of complement receptors at precise cell surface densities. An array of transcription factors binding to promoter elements of the complement receptor genes regulate complement receptor mRNA and,...
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