Professionals who work with children and adolescents who have developmental disabilities will find themselves working with a number of other professionals on various “teams.” These teams are typically composed of practitioners from more than one discipline working toward the single goal of providing comprehensive patient care. Research on medical and psychosocial teams confirms the overwhelming importance of clarity, commitment, and close positive exchanges among team members to promote successful teamwork. The effectiveness of teams is largely dependent on how the professionals work to accomplish meeting the needs of their patients. This chapter reviews multidisciplinary, interdisciplinary, and transdisciplinary approaches to delivering health care to children and adolescents who have developmental disabilities.