The authors present their views on the current state of the art for research focused upon religion/spirituality and quality of life. Because of the undeniable influence of religion and spirituality at the macro-level of cultures, the internal and external worlds of individuals embedded in any culture are touched by religion and spirituality – even for individuals who deny any religious affiliation or beliefs. Religion and spirituality has already attracted attention from QOL researchers across a wide set of disciplines and should continue to do so in the future. The authors discuss approaches, topics and methodological issues that should be considered when researching religion/spirituality and QOL. Recommendations for future research are set in italics.