Irreversible electroporation (IRE) is a promising new technique for the ablation of tumors and arrhythmogenic regions in the heart (Davalos, Mir et al. 2005; Edd, Horowitz et al. 2006; Al-Sakere, Andre et al. 2007; Edd and Davalos 2007; Onik, Mikus et al. 2007; Rubinsky 2007). One of its primary advantages over other ablation techniques lies in its mechanism to kill undesirable cells by affecting the cell membrane without thermally damaging major blood vessels, connective tissue, nerves and the surrounding tissue. IRE’s ability to create complete and predictable tissue ablation with sharp transition between normal and necrotic tissue will have great advantages in a variety of medical applications (Rubinsky 2007).