This study was a preliminary assessment of preferences for instruction strategies for promoting vocational activities with three persons with multiple disabilities. The instruction strategies were based on computer technology, on cards, and on staff supervision and cards. Results indicated that all three persons preferred the computer-based strategy over the other two. Their activity level was higher with the computer-based strategy and the strategy involving supervision than with the cards strategy. The reasons suggested to explain the persons' preference for the computer-based strategy were success in performance, sense of control over the instruction process, and friendliness and attractiveness of the strategy.