The Eye-RIS family is a set of vision systems which are conceived for single-chip integration using CMOS technologies. The Eye-RIS systems employ a bio-inspired architecture where image acquisition and processing are truly intermingled and the processing itself is realized in two steps. At the first step processing is fully parallel owing to the concourse of dedicated circuit structures which are integrated close to the sensors. These circuit structures handle basically analog information. At the second step, processing is realized on digitally-coded information data by means of digital processors. Overall, the processing architecture resembles that of natural vision systems, where parallel processing is made at the retina (first layer) and significant reduction of the information happens as the signal travels from the retina up to the visual cortex. This chapter outlines the concept of the Eye-RIS systems used within the SPARK project, these are, the Eye-RIS v1.1 vision system based on the ACE16K smart image sensor (used within the first half of the project) and the Eye-RIS v1.2 vision system which supersedes the v1.1 and is based on a new generation of smart image sensors named Q-Eye. Their main components, features and experimental data that illustrate its practical operation are presented as well in this chapter.