The paper reports the results of an experimental study on pressure drop during horizontal flow boiling of refrigerants R22, R507, R404A, R134a, R407C and R410A. The test section is a smooth, horizontal, stainless steel tube (6 mm I.D., 6 m length) uniformly heated by Joule effect. The experimental tests are carried out at an almost constant evaporating pressure of 7.0 bar varying the mass flow rate in the range 280–1,080 kg/m2 s. The experimental comparison clearly shown that the pressure drop of R22 is significantly higher as compared to all the other fluids. The results are compared against well-known pressure drop prediction methods. The available correlations can be used for both pure fluids and mixtures with no corrective factors, provided the mixture properties are evaluated at local compositions. The Chawla friction correlation is the best-fitting of our experimental data in combination with the heterogeneous momentum pressure drop model on the basis of the Rouhani-Axelsson void fraction correlation.