The present manuscript examines the conceptual and practical issues of cognitively-oriented psychotherapeutic methods to those individuals suffering from brain-injury. The manuscript briefly reviews various types of brain-injuries, associated cognitive and emotional changes, and the implications of cognitive deficits for the practice of cognitively-oriented psychotherapy. In particular, the practice of Rational-Emotive Behavior Therapy (REBT) with brain damaged individuals is discussed. The manuscript highlights the cognitive limitations of brain-injured individuals and the necessary adjustments required to develop more effective forms of cognitive psychotherapeutic intervention.