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Oral epithelial dysplasia, which is the precursor lesion for oral squamous cell carcinoma (oral SCC), presents an ideal opportunity for chemoprevention. First, oral dysplastic lesions are visible and can therefore be readily monitored during both the trial and recall phases of treatment. Secondly, in the event that local delivery chemoprevention will be used, the direct visibility enables agent placement...
It is estimated that oral cancers will present with more than 400,000 new cases worldwide, establishing this malignancy as the sixth most common cancer globally. In association with the “field” effects of these epithelial neoplasias, oral cancers are marked by high frequencies of local invasion and recurrence, and 5-year survival times of less than 60% depending upon the stage of the initial lesion...
Colorectal cancer (CRC) is the leading digestive tract cancer in the Western world, particularly in the United States where it accounts for approximately 10% of all cancer deaths. The multistage development of CRC is associated with chromosomal instability, DNA-repair defects, aberrant DNA methylation, and mutational events in oncogenes and tumor suppressor genes. Preclinical studies using cultured...
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