A new hyper-chaos communication system based on cellular neural network (CNN) is proposed in this paper. Hyper-chaos is generated with fifteen-cell CNN, then it’s transferred to a digital sequence. The chaotic sequence is better than gold sequence when they are utilized in direct sequence spread spectrum system. Compared with the traditional gold sequence system, there is 3dB improvement in CNN chaotic sequence system when the channel is multi-path channel. Because of the complex dynamic behavior of hyper-chaos, security signal could be transferred through wireless channel. The structure of hardware CNN spread spectrum system is also shown, and the security of CNN communication is analyzed at last.