Using the method of low-temperature 1H NMR-spectroscopy we investigated isotope effects in adsorption of water and hydrochloric acid by the surface of nanosilica A-300 and in particular dehydrated cells Saccharomyces cerevisiae. It is shown that replacement of protium by deuterium results in the growth of the amount of water bound with silica. Solutions of H(D)2O-H(D)Cl are characterized by the formation of several types of cluster structures different in concentration of acid. The ratio of intensities of signals corresponding to various types of clusters substantially depends on the isotope composition and for samples enriched with deuterium it shifts to the side of less associated forms of water.