Peritoneal dialysis (PD)-related infection encompasses PD-related peritonitis and catheter-related infections, and the latter is used as the collective term to describe exit site infection (ESI) and tunnel infection. Despite of the advances in technology and antibiotic therapy, PD-related infections remain common and serious complications of PD. Since 2016, the International Society for Peritoneal Dialysis (ISPD) has published revised guidelines on the treatment and prevention of peritonitis and catheter-related infections. The two sets of guideline include evidence-based review and opinion-based recommendations. In this article, I review the key points and major changes in the 2016/17 version of ISPD recommendations. The recent literature that resulted in these changes will be highlighted. Problems related to implementation of these recommendations in different countries will also be discussed.