The purpose of this paper is to provide sufficient conditions for the existence and uniqueness of fixed points for non-decreasing and mixed monotone mappings with auxiliary functions in the framework of metric space endowed with a partial order. As applications of our results we obtain several interesting corollaries and fixed point theorems in the underlying spaces. In order to illustrate our results, we provide two examples in which other theorems from the literature cannot be applied. In addition, the equivalence property between unidimensional and multidimensional fixed point theorems is investigated. We also present some applications to the existence of solutions of integral and differential equations.