A relatively new original concept of metabolic immunity is described based on long-term original clinical studies and confirmations from clinical testing. Multiple sclerosis (MS) and cerebrovascular disorders (CVDs) are a pressing problem, while their etiology is not completely understood, especially in the former case, and most likely involves many factors. However, metabolic immunity, which is associated with cell–tissue clusters of the body and providing a key link in the inseparable chain of systemic and local immunity, is a basic principle. Basic markers of the main bodily reactions and their relationships and the results of testing various immune preparations are reported. Various types of immune responses were identified, and a severity rating of laboratory changes in particular nosological forms was developed as a tool for effective immunotherapy.