Alkaline TiO2 nanoparticles treated cotton/polyester (50/50) blend fabric were prepared, and then exposed to UV irradiation. It was found that the addition of a small amount of TiO2 nanoparticles to the coating solution improves the hydrophilicity and mechanical strength of the fabrics. The treated fabrics exhibited high water absorption as well as better hydrophilicity compared to the untreated sample. Compared to the surface of untreated blend fabric, scanning electron microscopy showed that the surface of the modified blend fabric becomes rough and covered by a layer of other materials. Furthermore, X-ray diffraction demonstrated the formation of crystalline material. In addition, thermograms showed that the modification process improved the thermostability of blend fabric.