This work in devoted to numerical calculation of turbulent flow in a labyrinth-type throttle. A system of such throttles is installed at the inlet to the MBIR reactor’s low-pressure chamber and serves for setting up the required pressure difference and coolant flow rate. MBIR is a multipurpose fourthgeneration fast-neutron research reactor intended for investigating new kinds of nuclear fuel, structural materials, and coolants. The aim of this work is to develop a verified procedure for carrying out 3D calculation of the throttle using CFD modeling techniques. The investigations on determining the throttle hydraulic friction coefficient were carried out in the range of Reynolds numbers Re = 52000–136000. The reactor coolant (liquid sodium) was modeled by tap water. The calculations were carried out using high-Reynolds-number turbulence models with the near-wall functions k-ɛ and RNG k-ɛ, where k is the turbulent pulsation kinetic energy and ɛ is the turbulence kinetic energy dissipation rate. The obtained results have shown that the calculated value of hydraulic friction coefficient differs from its experimental value by no more than 10%. The developed procedure can be applied in determining the hydraulic friction coefficient of a modified labyrinth throttle design. The use of such calculation will make it possible to predict an experiment with the preset accuracy.