Intermolecular-interaction potentials for the H2O–Ne, H2O–Kr, and H2O–Xe systems have been determined from experimental broadening coefficients γ found for vibrational–rotational absorption lines in the ν2 band of water-vapor molecules in the corresponding mixtures at a temperature of T = 296 K. The rotational and vibrational corrections to the effective potentials are calculated. Broadening coefficients γ of the absorption lines of the H2O molecule are calculated for a wide range of rotational quantum numbers in the temperature range 300 K ≤ Т ≤ 600 K. A comparative analysis of the temperature dependences of the calculated broadening coefficients for the potentials in use is performed.