In our previous study, we observed younger OSAS patients had higher CPAP acceptance but similar compliance as older OSAS patients, suggesting gender factor might play an important role on CPAP acceptance. Hence, we aimed to evaluate the influences of both gender and age on CPAP acceptance and compliance in Taiwanese OSAS patients. This retrospective study included 371 subjects which were subdivided by gender and age (younger: age < 55 years, and older: age ≥ 55 years) (n = 24 for younger women, n = 67 for older women, n = 131 for younger men; and n = 149 for older men). Anthropometric parameters, blood pressures, Epworth sleepiness scale, polysomnography variables, CPAP acceptance, and CPAP compliance were collected and compared. Univariate analysis evaluated the influence of different variables on CPAP acceptance. Due to the presence of multicollinearity for N3 sleep and AHI, as well as N3 sleep and DI, multivariate logistic regression models were conducted using three different models with N3 sleep, AHI, and DI included separately. Univariate analysis found women had less CPAP acceptance than men. Multivariate logistic regression analysis indicated younger women had lower CPAP acceptance, but in contrast younger men had higher CPAP acceptance. No difference was observed among the four subgroups for long-term CPAP compliance. In conclusion, our findings suggest that both age and gender impact CPAP acceptance for treating OSAS in Taiwan, with women having lower CPAP acceptance than men regardless of age. No apparent influence of age and gender on CPAP compliance was observed.