With the rapid technological advances in acquiring data from diverse platforms in cancer research, numerous large scale omics and imaging data sets have become available, providing high-resolution views and multifaceted descriptions of biological systems. Simultaneous analysis of such multimodal data sets is an important task in integrative systems biology. The main challenge here is how to integrate them to extract relevant and meaningful information for a given problem. The multimodal data contains more information and the combination of multimodal data may potentially provide a more complete and discriminatory description of the intrinsic characteristics of pattern by producing improved system performance than individual modalities. In this regard, some recent advances in multimodal big data analysis for cancer diagnosis are reported in this article.