In this study, a macro-nanocomposite of Al–Al/(SiO2)np was synthesized using powder-in-tube method. Pure aluminum cylinders were cast and then machined to prepare tubes. Nanocomposite powders of Al/(SiO2)np were prepared by mixing 1 and 2 wt% SiO2 nano-particle with aluminum. Then macro-nanocomposites were prepared by compaction of the nanocomposites inside the tubes. The effects of reinforcement weight fraction, volume fraction of nanocomposite in the macro-nanocomposites and hot extrusion on the microstructure and mechanical properties were investigated. Scanning electron microscope (SEM) and optical microscope (OM) were used for microstructural examinations. Mechanical properties were investigated using tensile and compression tests at room temperature. The results revealed that when 25 vol% of the powder-in-tube composite was the nanocomposite reinforced with 2 wt% of nano-particle, the tensile strength was increased by 10.8%. Tensile strength was improved by up to 24% when 64 vol% of nanocomposite reinforced with 1 wt% of nano-particle was employed. Additionally, significant increase in compressive strength was achieved. This is noteworthy that coupling of a pure aluminum sheath with the nanocomposite enhanced the strength with limited loss of ductility. Micrographs showed integrated composites in which the interface between the sheath and the core had no defects.