Purpose of Review
One in eight women in the USA will develop breast cancer in her lifetime. Despite established efficacy, the use of pharmacotherapy for breast cancer prevention is limited by concerns over toxicities that may negatively influence quality of life. Additional interventions for breast cancer prevention are needed.
Recent Findings
There is emerging evidence from observational studies that obesity, physical inactivity, sedentary behavior, and dietary patterns are associated with breast cancer risk. Randomized trials are necessary to provide unbiased efficacy estimates of lifestyle changes on breast cancer risk, but such trials require a large sample size, long-term follow-up, and substantial financial investment. One approach to manage these barriers is to leverage recent advances in precision prevention to identify high-risk study participants to reduce sample size or shorten length of follow-up.
Summary
Precision prevention approaches may accelerate the translation of epidemiologic discoveries into proven population-based breast cancer prevention interventions.