Climate change, environmental challenges, population growths and depletion of natural resources are some of the major challenges of this century. Therefore, the global societal pressure and thus political ambitions are growing to transform our highly industrialized economy towards a so called “bio-economy”. As one solution integrated biorefinery concepts are discussed, which convert biomass with minimal energy consumption to a multitude of products (food, fodder, energy, materials) without generating waste. But besides the development of new and innovative biorefinery concepts, integration of available structures is quite important especially during the transformation of our industrial society into a bio-economy. Against this background the goal of this contribution is to discuss the potential role of existing small to medium sized biogas plants as an integral part of advanced biorefinery concepts. By presenting four case studies several approaches are discussed within this paper. Even if some of the presented technologies are still characterized by a low technology readiness level, they show a high potential in terms of increasing the monetary value addition of the biomass and in terms of enhancing the overall process efficiency.