A grinding experiment was conducted with Ti-6Al-4V alloy in a wet and cryogenic coolant environment. An electroplated cubic boron nitride grinding wheel was used for this experiment. The input process parameters that were considered were depth of cut and nozzle inclination angle. The output response parameters that were considered were tangential forces, normal forces, grinding zone temperature, specific energy, and surface roughness (Ra). Experimental results indicate an 8% to 27% reduction in tangential force and 3% to 12% reduction in normal force when liquid nitrogen was used as coolant. Ra is reduced by a maximum of 38% over wet grinding, and grinding zone temperature is reduced by up to 55%. Surface modification and chip morphology were analyzed. Experimental results indicated that the nozzle angle at 45° has a significant effect on the grinding process.