In this work, a green and efficient methodology has been developed for the synthesis of 1,2,3-triazoles by ‘copper nanoparticles supported on nanocellulose (CuNPs/NC)-catalyzed azide-alkyne cycloaddition reaction in glycerol, an environmentally benign solvent, with excellent yields. The present catalyst was characterized by TEM, XRD, SEM-EDX and FT-IR spectroscopy. The reusability of the prepared nanocatalyst was examined up to five times without significant loss of catalytic activity.
Graphical Abstract:SYNOPSIS: A catalyst of copper nanoparticle supported on highly crystalline nanocellulose was prepared and was effectively used for the important regioselective synthesis of 1,4-disubstituted 1,2,3-triazole from the 1,3-dipolar cycloaddition of various azides and alkynes.